Andronikos Palaiologos Kantakouzenos

Andronikos Palaiologos Kantakouzenos (died 4 June 1453) was the last Grand Domestic of the Byzantine Empire. Present in the city at the Fall of Constantinople in 1453, he was one of the group of high Imperial officials executed by Ottoman Sultan Mehmet II five days after the city was taken.

Andronikos was amongst those who advised Emperor Constantine XI Palaiologos to take for his third wife Anna, the daughter of Emperor David of Trebizond, instead of Mara, the daughter of Đurađ Branković, despot of Serbia. His name appears on the treaty between Byzantium and Venice concluded in April 1448, in place of Demetrios Palaiologos Kantakouzenos, who was indisposed at the time.

He is likely the Grand Domestic Kantakouzenos whom Emperor John VIII Palaiologos sent in the fall of 1436 to persuade the Serbians to send a delegation to the Council of Ferrara-Florence concerning the Union of Churches. The historian Sylvester Syropoulos describes this man as the "brother-in-law of the Despot of Serbia"; Andronikos Palaiologos Kantakouzenos was the brother of Irene Kantakouzene, wife of Đurađ Branković.