Alexandra F. Freeman

Alexandra F. Freeman is an American physician-scientist specializing in pediatric infectious diseases and primary immunodeficiencies. She is a senior clinician at the National Institute of Allergy and Infectious Diseases (NIAID), where her research focuses on hyperimmunoglobulin E syndromes and immune disorders.

Education Freeman earned a B.A. in biology from Carleton College in 1992. She received a M.D. degree from Georgetown University School of Medicine in 1997. Following medical school, she completed a pediatrics residency at Yale New Haven Children's Hospital from 1997 to 2000. In 2005, she shifted her focus to primary immunodeficiencies, including hyperimmunoglobulin E syndromes. She has studied patients with STAT3-mutated Hyper-IgE syndrome (STAT3 DN; Job's syndrome), which involves eczema, recurrent infections, and connective tissue abnormalities.

Her research has examined the role of STAT3 in immunity, infection susceptibility, and tissue remodeling. She has also investigated treatment options, including hematopoietic stem cell transplantation and gene editing. Freeman is the director of the primary immunodeficiency clinic at NIAID, where she trains allergy and immunology fellows in diagnosing and managing primary immunodeficiencies.